A Pulitzer Prize winning novel, the thread of the plot is the genetic history, over three generations of a Greek family, of the recessive gene for 5-alpha-reductase that affects sexual development. But the heart of the story is the saga of the family from the immigration in the early 1920’s of a man and a woman from the violence and destruction of their native village to their assimilation into Detroit, Michigan. It also chronicles the history of Detroit as it develops into the automobile manufacturing giant it becomes. Told with humor and insight by the member of the third generation who is born with two copies of the gene as he/she copes with gender identity and moves to San Francisco as a young adult where he comes to terms with his identity.